PRNP and cancer: Other pathological conditions, in contrast, may rather require inhibition of PrPC shedding: it is intriguing that both, ADAM10 [118, 119] and PrPC, have been linked with immune signaling and chronic inflammatory processes [120, 121] as well as with tumorigenesis and cancer progression [122–124], where expression levels of these two proteins generally correlate with poor prognosis.