In support of our novel finding, studies from other groups have already shown that the key components of NuRD complex, including MTA1, MTA3, and Mi-2 (CHD4), and other NuRD interacting proteins such as LSD1, directly control the invasive growth, epithelial-to-mesenchymal transition, and metastasis in breast cancer [24–26]. This evidence concerns the gene CHD4 and breast carcinoma.