Previous studies have shown that stromal cell–derived TSG-6 interacts with CXCL8 and suppresses the infiltration of neutrophils in inflammatory conditions such as acute pancreatitis.10,31 At the eye, TSG-6 has been shown to attenuate the recruitment of neutrophils to the cornea after chemical and mechanical injuries.3 It is interesting that neutralization of TSG-6 in our stromal cell–neutrophil coculture assays did not abrogate the suppressive effects of stromal cells on MPO and ELANE secretion by neutrophils. The gene discussed is ELANE; the disease is acute pancreatitis.