Growing evidence indicates that decreases in tau O-GlcNAcylation may contribute to tau pathology in AD [23], whereas increasing tau O-GlcNAcylation with Thiamet G, a selective OGA inhibitor, reduces the formation of tau aggregates and protects against neuronal degeneration in a mouse model of tauopathy [24]. The gene discussed is MAPT; the disease is Alzheimer disease.