In addition, the kinetics of CD4+ T-cells in the genital tract of TLR3-/- mice during the early and middle stages of infection is similar to what is observed during C. muridarum infections in BALB/c and C57BL/6 mice showing that Th1 T-cells remain high after 3 weeks post-infection [10, 74, 75]. This evidence concerns the gene CD4 and infection.