TLR3 and chlamydia trachomatis infectious disease: In contrast, the TLR3-/- mice secreted higher levels of IL-10, TNF-α and IFN-γ than wild-type mice (Fig 4C, 4D and 4F) at day 7 of infection, suggesting that TLR3 deficiency did not result in a global downregulation in synthesis of cytokines during early stages of chlamydial infection.