IL10 and chlamydia trachomatis infectious disease: Because IL-10 dysregulation is also possibly associated with outcomes of infection that are indicative of chronic sequalae of chlamydial disease [66], it is possible that the TLR3 signaling pathway either directly or indirectly regulates IL-10 synthesis as a way to limit genital tract pathology in the wild-type mice, and that putative regulation is absent in the TLR3-deficient mice.