TRIM22 was previously shown to inhibit the replication of seasonal IAV strains (12); in order to test whether it could also interfere with the replication of the 2009 pandemic H1N1 strain, MDCK cells stably overexpressing a TRIM22 protein fused to the HA tag or control MDCK cells were infected at low multiplicity of infection (MOI [0.001]) with A/Paris/7608/2009 virus (pH1N1). The gene discussed is TRIM22; the disease is infection.