Observations in LNCaP and DU145 cells show that ZEB1 mediates the effect of FOXC2 on tumor-initiating potential and drug resistance (Paranjape et al., 2016), traits that are often correlated with EMT (Jolly et al., 2014; Jolly et al., 2015; Mani et al., 2008; May et al., 2011; Morel et al., 2008). Here, FOXC2 is linked to neoplasm.