These models represent different mathematical realizations of the same core EMT circuit – miR-34/SNAIL/miR-200/ZEB1 – and both highlight that EMT is not an ‘all-or-none’ response (Jolly et al., 2015; Gupta et al., 2011; Huang et al., 2014; Boareto et al., 2015), reminiscent of other similar examples of cellular plasticity (Jolly et al., 2015) in tumor progression. Here, ZEB1 is linked to neoplasm.