Considering the observations across the board that 5hmC levels are significantly reduced in malignancies compared to their healthy matched tissue (Figueroa et al., 2010; Ko et al., 2010; Jin et al., 2011), the presence of detectable 5caC in brain tumors may seem rather unexpected and may depend on certain specific features of their methylation/demethylation machinery influenced by overexpression of WT1 and or TET2/IDH1 & 2 mutations in these cancers. Here, WT1 is linked to brain neoplasm.