Moreover, WT1 has been demonstrated to bind directly to TET2 and TET3 recruiting them to their potential target sequences in acute myeloid leukemia models where mutation of WT1 resulting in its inactivation is accompanied with significant locus specific diminishing of 5hmC levels, a phenotype mimicked by mutations in the isocitrate dehydrogenase genes (IDH1/2) (Verhaak et al., 2010; Rampal et al., 2014; Kelly et al., 2017). This evidence concerns the gene IDH1 and acute myeloid leukemia.