WT1 and brain cancer: WT1 wildtype mRNA has been detected in a range of malignancies including oesophageal, gastric, colorectal, pancreatic, biliary, lung, prostate, renal, breast, cervical, ovarian, endometrial, soft tissue, and brain cancers, indicative of a possible oncogenic contribution of ectopic WT1 expression in tumorigenesis (Nakatsuka et al., 2006).