CDK6 and brain neoplasm: Despite 5hmC depletion within aggressive brain tumor grades, its presence within genomic features appears critical to glioblastoma pathogenicity with the enrichment of 5hmC identified in gene regulatory regions upstream of core glioblastoma signaling genes such as epidermal growth factor receptor vIII (EGFRvIII) and cyclin-dependent kinase 6 (CDK6) (Johnson et al., 2016).