CHTOP and glioblastoma: Core GBM signaling pathway genes e.g., BRAF, AKT, EGFR, & CDK6 possessed 5hmC enrichment at their promoters and intergenic regions which positively correlated with chromatin target of PRMT1 (CHTOP) promoter presence and binding and consequent transcriptional activation of these genes (Takai et al., 2014).