In this context, it is striking that our recent studies have highlighted an enrichment of 5caC not only in certain types of pediatric brain tumors such as medulloblastomas and ependymomas (Ramsawhook et al., 2017) but also in a number of samples of glioblastoma multiforme (Eleftheriou et al., 2015), a cancer previously reported to possess elevated levels of WT1 (Schittenhelm et al., 2008). Here, WT1 is linked to brain neoplasm.