Short hairpin RNA (shRNA) molecules targeting WT1 mRNA transiently silence WT1 gene expression and reduce glioblastoma cell proliferation, viability, and invasion ability suggesting an oncogenic role for WT1 in these malignancies as opposed to the tumor suppressor role this protein plays in Wilms' tumor (Schittenhelm et al., 2008; Clark et al., 2010; Kijima et al., 2016). This evidence concerns the gene WT1 and Nephroblastoma.