Abbreviations: chRNA, chimeric RNA; AML, acute myeloid leukemia; NK, normal karyotype; UK, unknown karyotype; AK, abnormal karyotype; APL, Acute Promyelocytic Leukemia; PBMCs, peripheral blood mononuclear cells; Inv16, chromosome 16 inversion; t(15;17), translocation of chromosomes 15 and 17; qPCR, quantitative polymerase chain reaction; NONE, non-annotated region; LincRNA, Long intergenic noncoding RNAs; Bcr, break chromosomal region; FISH, Fluorescencein situ hybridization; ATRA, all-trans retinoic acid; VD, vitamin D; TGFβ, transforming growth factor beta; MRD, minimal residual disease. The gene discussed is TGFB1; the disease is acute myeloid leukemia.