Furthermore, experimental results show that membrane TNF/TNFR2 interactions, in combination with CD80/CD28 interactions between monocytes and CD8+ T cells from RA patients, could also promote the induction of CD8+Foxp3+ Tregs in vitro, while combined CD86 and TNF blockade completely ablated the process (44). This evidence concerns the gene TNF and rheumatoid arthritis.