IGFBP3 and esophageal cancer: IGFBP-3 has been identified in the cell nucleus in a variety of healthy and cancerous human tissues, including non-malignant colon (27), lung (28), articular cartilage (29), and bone (30), as well as malignant colon (27), liver (31), Barrett’s tissue associated with esophageal cancer (32), and prostate (18) [including reactive stroma (33)] tissue.