IL10 and systemic sclerosis: Three SNPs in the IL-10 intron region (rs1554286, rs1518111, and rs3024490) have been reported to be associated with risk for ischemic stroke and idiopathic recurrent miscarriage (43–45), and two SNPs in the IL-10 promoter region (rs1800871 and rs1800896) have been identified as highly polymorphic risk factors for systemic sclerosis (46) and Alzheimer’s disease (47).