Nonetheless, SILK–SIMS may also be applied to measuring other proteinaceous deposits such as Lewy bodies (alpha-synuclein), neurofibrillary tangles (tau), and prion protein, which are characteristic of Parkinson’s disease, frontotemporal dementia and AD, and Creutzfeldt–Jakob disease, respectively. The gene discussed is MAPT; the disease is frontotemporal dementia.