VEGFA and cancer: WFA is reported to exert anti-angiogenic effects in some cancers and to effectuate the role of WFA as anti-angiogenic agent in PF, some of the significant target proteins of angiogenesis like p-p38 MAPK (mitogen activated protein kinase), p-VEGF (vascular endothelial growth factor), p-FAK (focal adhesion kinase), and p-PLCγ1 (phospholipase C) were evaluated (Figure 4B).