Epithelial to mesenchymal transition and extracellular matrix (ECM) are considered as crucial developmental milestones in PF wherein, a pivotal fibrogenic cytokine TGF-β is aberrantly expressed, which in turn triggers EMT process thereby enhancing ECM deposition mediated by both Smad dependent and independent pathways (Verrecchia and Mauviel, 2002; Kasai et al., 2005; Kolosova et al., 2011; Todd et al., 2012; Zhang, 2017). Here, TGFB1 is linked to pemphigus foliaceus.