MAPT and familial Alzheimer disease: Raja et al. (2016) developed brain organoids from iPSCs derived from patients with fAD. The organoid successfully recapitulated Aβ aggregation, hyperphosphorylated tau, and endosome abnormalities. Treatment with β-secretase and γ-secretase inhibitors reduced the Aβ and tau pathology. Lee et al. (2016) generated a three-dimensional neuro-spheroid culture from blood cell-derived iPSCs from patients with sAD.