TARDBP and amyotrophic lateral sclerosis: Recent reports have shown that TDP-43 is a nuclear protein that can translocate from the nucleus to the cytoplasm to form ubiquitin-positive inclusions (UPIs) that are neurotoxic in ALS and FTLD (Porta et al., 2015; Halliday et al., 2016; Mashiko et al., 2016).