In hippocampal neurons from the PSEN1KI or the APP-knockin (APPKI) mouse models of AD and in human sporadic AD cortical samples, downregulation of STIM2 protein disrupts neuronal SOCE thus inhibiting the continuous Ca2+ influx necessary for sustained calmodulin kinase II (CaMKII) activation that is, in turn, essential for the stability of mushroom spines (Sun et al., 2014). This evidence concerns the gene STIM2 and Alzheimer disease.