TRPC6 and Alzheimer disease: Regarding SOCE, its positive modulator NSN21778 rescues mushroom spine loss in both PSENKI and APPKI mouse models of AD (Zhang et al., 2016); while, its induction through overexpression of STIM2 or following pharmacological stimulation of TRPC6 is beneficial in AD animal models (Sun et al., 2014; Zhang et al., 2015b, 2016).