In another triple transgenic AD mice (3xTg-AD) with transgenes APPswe, PS1M146V, and TauP301L, mitochondrial impairment was early evidenced by impaired mitochondrial respiration, and decreased pyruvate dehydrogenase (PDH), as well as increased oxidative stress (Yao et al., 2009). Here, PDP1 is linked to Alzheimer disease.