HLA-C and autoimmune disease: If intra-individual MHC diversity is the result of a trade-off between ensuring efficient presentation of pathogen-derived peptides and some selective force acting against high MHC diversity (e.g. T-cell repertoire depletion, necessity to ensure a high level of antigen presentation or risk of autoimmune diseases), individuals with a MHC diversity just high enough to present peptides of locally abundant parasites and pathogens efficiently will be selected.