A mouse model of AngII infusion was used to study the effects of ADAMTS-5 on aortic dilatation, which may not recapitulate all aspects of human aneurysmal disease, in particular with regards to hemodynamics and mechanotransduction.44,45 Also, the relative importance of different members of the ADAMTS family may differ between species. The gene discussed is ADAMTS5; the disease is Vascular dilatation.