ADAMTS1 and Hepatic fibrosis: Interestingly, it has also been shown that the latent form of TGF-β can be associated and subsequently activated by the C-terminal region of ADAMTS-1, thereby enhancing the inflammatory response in liver fibrosis.35 In agreement with these results, we found a direct correlation between ADAMTS-1 and TGF-β regulation in ADAMTS-5Δcat mice on AngII treatment.