AGT and hypertensive disorder: Loss of ADAMTS-1 has recently been implicated in TAA.3 Thus, we assessed aortic dilatation in mice lacking the region encoding for the catalytic domain of Adamts5 (Adamts5Δcat).21 Hypertension was induced in Adamts5+/+ and Adamts5Δcat mice by AngII infusion for 4 weeks (Figure I in the online-only Data Supplement).