Hou L et al. screened SOD1, TARDBP, and FUS gene mutations in ALS patients from central-southern China and revealed that SOD1 (20%) and FUS (13.3%) mutations were the main causal mutations in familial ALS, but they did not detect any TARDBP-linked ALS families [9]. The gene discussed is FUS; the disease is amyotrophic lateral sclerosis.