However, with the addition of NMDA and 7,8-DHF (NMDA receptor agonist and TrkB agonist), the inhibition of learning and memory of rats were improved, suggesting that the NMDA receptor and BDNF-TrkB signaling pathway may play a significant role in propofol-induced learning and memory impairment. The gene discussed is BDNF; the disease is memory impairment.