Compared to healthy controls, otitis-prone children had small but significantly increased frequencies of CD107a+ CD8+ T cells in response to SEB (p<0.01, Fig 5B), NTHi86-028NP (p = 0.06, Fig 5C), and NTHi289 (p<0.05, Fig 5D). The gene discussed is CD8A; the disease is ear infection.