Among genes frequently mutated (defined as 7 or more variations in that gene across the 38 sequenced samples), 8 genes were significantly downregulated (p < 0.01) in tumor samples (CAMK1G, MINK1, PARD6A, CDC42BPA, CDC42BPB, MAP3K9, RPS6KA5) and 17 genes were significantly upregulated (p < 0.01) in tumor samples (MYC, ACVR1, NTRK1, MAPKAPK2, IL-13RA1, IL-13RA2, TP53, CLK2, HIST1H3B, ABL2, IL2RG, DDR2, MAPK7, PSENEN, STK36, H3F3A, IKBKE). The gene discussed is MAPKAPK2; the disease is neoplasm.