EIF2AK4 and ulcerative colitis: Furthermore, transcriptome meta-analysis performed on publicly available microarray datasets (Gene Expression Omnibus [GEO], Array Express) from samples of human inflammatory bowel disease (IBD) patients reveals that GCN2 was significantly down-regulated in the peripheral blood mononuclear cells (PBMCs) of both ulcerative colitis (UC) and Crohn’s disease (CD), whereas it was up-regulated in colon tissues (S10A–S10C Fig).