As misregulations of WNT5A, ROR1, ROR2 and KIF26B expression/function have all been implicated in the pathogenesis of human diseases including cancer and congenital disorders [11,40,41,42,43,44,45,46,47], delineating the precise mechanism(s) by which pathway components, such as GSK3, modulate flux through the pathway should facilitate the development of therapeutic agents that target the pathway. The gene discussed is ROR1; the disease is cancer.