The PAX8 expression profile has been evaluated in two series of 1100 and 1200 normal and tumour tissues and demonstrated a strong sensitivity in ovarian carcinomas (79% to 99%), endometrial carcinomas (84% to 93%), cervical adenocarcinomas (84%), renal cell carcinomas (90% to 100%), thyroid carcinomas (100% of follicular, papillary and poorly differentiated, 79% of anaplastic carcinomas and 75% of medullary carcinomas) [20,21]. Here, PAX8 is linked to hereditary clear cell renal cell carcinoma.