Aligned with the evidence above, the expression of key cell cycle regulators, like Cyclin Dependent Kinase 1 (CDK1) and Mitotic Arrest Deficient 2 (MAD2), was modulated by TRAP1 in a large cohort of colorectal, breast and lung adenocarcinoma cell lines, with consequent effects on mitotic entry [46]. This evidence concerns the gene CDK1 and lung adenocarcinoma.