However, the correlations between TRAP1 molecular functions and their effect in tumor cells are still controversial; some authors suggest that TRAP1 oncogenic potential also depends on the chaperone scavenging activity [50] and not only on its ability to induce pseudohypoxia through the inhibition of SDH, with subsequent accumulation of the HIF1α-stabilizing metabolite succinate. The gene discussed is SDHB; the disease is neoplasm.