Interestingly while all described mouse models carrying mutations or deletion of Lamin A do not show disease features in heterozygous, some evidence reported progressive electrophysiological cardiac abnormalities commencing around 4 weeks after birth and the emergence of late-onset cardiomyopathy in aged (50 weeks) heterozygous Lmna Δ8-11 mice, suggesting a cardiac pathology [87]. This evidence concerns the gene LMNA and cardiomyopathy.