The observation that AKT-mammalian target of rapamycin pathway is hyperactivated in the Lmna-mutation-caused cardiomyopathy has paved the way for the in vivo administration of the rapamycin-analog temsirolimus [150]; the inhibition of mTORC1 inhibition reactivates autophagy and prevents cardiac damage in Lmna H222P/H222P mice. Here, AKT1 is linked to cardiomyopathy.