Furthermore, since P2Y6 receptors are also expressed on activated microglia in the hippocampus of rats [43] and considering that obesity promotes hypothalamic inflammation, including the activation of microglia [44], this purinergic receptor could hold a potential pathophysiological role in inflammatory processes within the CNS induced by HFD. This evidence concerns the gene P2RX4 and obesity due to melanocortin 4 receptor deficiency.