GAD1 and type 1 diabetes mellitus: Antibody characteristics might facilitate diagnosis and estimation of risk for disease progression because high-affinity GADA responses against the middle (amino acids [aa] 235–444) and C-terminal (aa 445–585) domains of the 65 kDa isoform of GAD (GAD65) were associated with type 1 diabetes development in children and adolescents [5]; and high antibody titre [6] and binding to C-terminal (aa 437-585) GAD65-depending epitopes were reported as characteristic features of LADA individuals [7].