INS and Hypoglycemia: It was also found that the switching from twice-daily basal insulin to once-daily Glar-300 or Glar-100 led to reductions in HbA1c, with comparable decreases in both treatment groups and a lower risk of nocturnal confirmed or severe hypoglycemia observed with once-daily Glar-300 versus once-daily Glar-100 in participants switching from twice-daily basal insulin.