More hypoglycemic events in people with T2DM occurred during the day rather than at night in the EDITION 1, 2, and 3 trials (possibly related to prandial rather than basal insulin in the EDITION 1 trial); however, the prolonged action of Glar-300 may have caused a relative shift of long-acting insulin action from night to day. The gene discussed is INS; the disease is type 2 diabetes mellitus.