The authors concluded that, in the EDITION 1 trial, rates of hypoglycemia were likely confounded by the fact that patients were taking mealtime insulin in addition to basal insulin and that participants in the EDITION 3 trial were insulin naïve prior to the study and experienced fewer hypoglycemic events than those in the EDITION 1 and 2 trials (which possibly affected the ability to detect differences in the rates of hypoglycemia between the Glar-300 and Glar-100 groups in the EDITION 3 trial) [70]. Here, INS is linked to Hypoglycemia.