NUCKS1 and acute lymphoblastic leukemia: In addition to the in vivo studies mentioned above, the following in vitro studies showed the same results; in childhood acute lymphoblastic leukemia (ALL), compared with NUCKS1 expression in Reh cells overexpressing a scrambled control miRNA, NUCKS1 is downregulated in Reh cells overexpressing miR-125b, miR-99a, and/or miR-100 [57].