Omentin-1 is a newly identified adipocytokine and plays functional roles in inflammation, metabolic disorders and cardiovascular diseases.6–8,25–29 Our previous studies revealed that omentin-1 could inhibit osteoclast differentiation and ameliorate estrogen deficiency-induced bone loss by downregulating osteoblast RANKL/OPG ratio.9 These features make omentin-1 a promising candidate for the treatment of inflammation-induced osteoporosis. This evidence concerns the gene TNFRSF11B and osteoporosis.