Two SUDEP patients and one living epilepsy patient had rare variants in TTN (codes for a large protein in cardiac and skeletal muscle; disorders including cardiomyopathy and myopathy with early respiratory failure; OMIM: 188840) and CACNA1H (calcium channel, voltage-dependent, T Type, alpha 1 H subunit; disorders include tonic–clonic and febrile seizures; OMIM: 607904) though the loci were unique. Here, TTN is linked to epilepsy.