KCNH2 and chronic obstructive pulmonary disease: Other SUDEP molecular autopsy series identified known and suspected pathogenic variant in genes associated with lethal arrhythmia risk, such as LQT2 and Brugada syndrome.11,12,30 While these genes may increase SUDEP risk by lowering the threshold for cardiac arrhythmias during the fatal postictal cascade, cardiac arrhythmia was not observed in any of the ten SUDEP cases with concurrent EEG and ECG monitoring.31 The contribution of these variants to SUDEP risk in the general population remains unclear.