All variants are distinct from those previously associated with SUDEP cases in molecular autopsy series.11,12 Prior observation on mutations in specific genes in SUDEP cases (e.g., KCNH2, DEPDC5, LQT1, LQT2, LQT3 and ANK2) were not observed in our SUDEP cases or living epilepsy controls. The gene discussed is DEPDC5; the disease is Sudden unexpected death in epilepsy.