Some of these genes are associated with human disease: KCNMB1 - resistance to diastolic hypertension (OMIM: 608622)17; DPP6 - paroxysmal familial ventricular fibrillation type 2 and idiopathic ventricular fibrillation (OMIM: 126141)18; JUP - Naxos disease, a recessively inherited condition with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) and a cutaneous abnormalities (OMIM: 173325).19,20 We found no reports implicating TUBA3C/TUBA3D (OMIM: 602528) variants in arrythmogenic sudden-death risk. Here, TUBA3C is linked to paroxysmal familial ventricular fibrillation.