Because our FSPCre-Pparb/d−/− mice uniquely recapitulated the cell:cell signaling aspect of fibroproliferative 2 subtype of human SSc, we separated the epidermis and the dermis of FSPCre-Pparb/d−/− mice skin to analyze their compartment-specific gene expression by microarray. This evidence concerns the gene PPARD and systemic sclerosis.