P53 has also been shown to be associated with the epithelial-mesenchymal transition (EMT), a process which stimulates epithelial cells to acquire the invasive and metastatic properties of mesenchymal cells [13] and has thus been demonstrated to play a critical role in promoting metastasis of epithelia tumors [14] including CRC [15, 16]. This evidence concerns the gene TP53 and colorectal carcinoma.