Because of the important role of the TLR-4 signaling pathway in inflammation, we tested whether AM/SM could ameliorate LPS-induced ALI through regulation of TLR-4, IRAK-1, and NF-κB/p65 in this study, hypothesizing that it could explain the possible role of AM/SM in the protection of inflammatory response-induced lung injury. This evidence concerns the gene IRAK1 and acute respiratory distress syndrome.