Interestingly, we did not observe this downregulation of MKP-1 mRNA expression in the draining lymph nodes (DLNs) upon IMQ treatment (Figure S1B in Supplementary Material), as well as in skin tissue of 2,4-dinitrofluorobenzene-mediated Th1-type or fluorescein isothiocyanate-mediated Th2-type dermatitis (Figures S1C,D in Supplementary Material), indicating that the regulation of MKP-1 mRNA levels shows certain specificity in different stimuli stimulation or different disease models. The gene discussed is DUSP1; the disease is skin disorder.