AGT and hypertensive disorder: The involvement of ROS in the etiology of hypertension has been demonstrated in several animal models of hypertension: spontaneously hypertensive rat (Kerr et al., 1999), the angiotensin II-infused rat (Haugen et al., 2000), renovascular hypertension (Lerman et al., 2001), the deoxycorticosterone acetate-salt model (Wu et al., 2001), and obesity-related hypertension (Dobrian et al., 2001).