These findings, besides showing reversion of altered malprogramming structures and functions due to adverse prenatal conditions, are in favor of the potential usefulness of the L/G ratio measurement in adulthood as a clinical non-invasive marker of programmed susceptibility to develop obesity-related alterations; furthermore, it also seems to be able to detect the reversion of these disruptions by early life treatment, being more sensitive than leptin or ghrelin alone. This evidence concerns the gene LEP and Obesity.