Indeed, chronic stress reportedly accelerates AD pathogenesis in human and animal models through increases in inflammatory responses, Aβ accumulation, tau hyperphosphorylation, oxidative stress, mitochondrial impairment, and glucose metabolism (Machado et al., 2014), while early-life stress increases the risk of cognitive disorders in an aged mouse model of AD (Hoeijmakers et al., 2017). Here, MAPT is linked to Alzheimer disease.