The mutations in the EGFR lead to EGFR overexpression (known as upregulation) and its high expression can promote the proliferation, adhesion, invasion and metastasis of tumor cells [2] and is closely associated with non-small cell Lung cancer, breast cancer, gastric cancer, pancreatic cancer, colorectal cancer and other malignant tumors [3, 4]. The gene discussed is EGFR; the disease is colorectal cancer.