Although, in certain cases, these compounds can specifically interact with the altered pathways of cancer cells [5]; the structural and physical differences of these compounds suggest that their ability to activate the antioxidant response elements (AREs) of many cytoprotective genes through the cytoplasmic oxidative stress system, Nrf2-Keap1 (Kelch-like ECH-associated protein 1), is perhaps a common mechanism of action. Here, KEAP1 is linked to cancer.