Moreover, phloretin was shown to induce apoptosis of non-small-cell lung cancer (NSCLC) cell line A549, Calu-1, H838, and H520 (IC50 approx. from 50 to 100 μM) through deregulation of Bcl-2 [259] and other ROS-related pathways, such as P38 MAPK and JNK1/2 [260] which are related to the rise of ROS. This evidence concerns the gene MAPK8 and non-small cell lung carcinoma.