Curcumin affects various biochemical and molecular cascades involved in cancer by acting on a multitude of molecular targets including NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells), Akt, MAPK (mitogen-activated protein kinases), p53, Nrf2, Notch-1, JAK (Janus kinase)/STAT (signal transducer and activator of transcription), β-catenin, and AMPK (5′ adenosine monophosphate-activated protein kinase) [86]. This evidence concerns the gene TP53 and cancer.