KEAP1 and cancer: Indeed, the Nrf2/Keap1 pathway is activated by quercetin [48], fisetin [49], piperlongumine [50], and phloretin [51] as well as by different cannabinoids [52], tocotrienols [53], and a multitude of anticarcinogenic natural compounds that were found to cause cancer cell apoptosis or senescence under certain conditions (Figure 1).