Adding to this field, we have recently published that during the acute inflammatory process of community-acquired pneumonia (CAP), the circulating AAT molecule differs due to variations in its glycosylation pattern and that AAT glycans containing 4 sialic acids appeared during the resolution phase of CAP.16 Moreover, data highlight the role of sialylation in the anti-inflammatory activity of AAT, as during the resolving phase of infection there was a significant increase in circulating levels of interleukin (IL)-8 complexed to sialylated negative glycoforms of AAT. The gene discussed is SERPINA1; the disease is infection.