Our results reinforce the central role of muscle stem cells, so called satellite cells, in the muscular forms of laminopathies by showing Lmna−/− H-2K myoblasts precocious differentiation due to the alteration of a crucial signaling pathway implicated in the maintenance of stem cells proliferation and the prevention of premature differentiation: the BMP4 pathway. The gene discussed is BMP4; the disease is laminopathy.