Additionally, miR-9 down-regulation was observed in induced pluripotent stem cell derived neurons from an ALS patient with a TDP-43 mutation63, whereas miR-155, which is increased in the spinal cord of ALS patients, was suggested as a therapeutic target and its inhibition extended surivival in SOD-1-G93A mice36. Here, TARDBP is linked to amyotrophic lateral sclerosis.