SOD1 and amyotrophic lateral sclerosis: However, only miR-155, which is increased in the spinal cord of ALS patients, has so far been used as a non-muscle therapeutic target in ALS, its inhibition extending the survival SOD-1-G93A mice36, despite promising results with myomiR targeting in other muscle disorder models such as Duchenne muscular dystrophy and spinal and bulbar muscular atrophy37,38.