We found that the expression of lysosomal biogenesis genes such as hexosaminidase A (HEXA), lipase A (LIPA), cathepsin B (CTSB), cathepsin D (CTSD) and ATPase, H+ transporting, lysosomal V0 subunit A1 (ATP6VOA1) was significantly upregulated in hearts of TB mice (Fig. 4b). This evidence concerns the gene CTSD and tuberculosis.