No GWAS has been published to date relating arrhythmia to genetic variation in desmocolin cluster genes, including DSC3. The desmocolin gene cluster is of interest because the desmocolins are calcium-dependent glycoproteins involved in cardiac intercellular connections and neighboring gene DSC2 is associated with ACM, a congenital heart disorder characterized by right ventricular fibrofatty infiltration, myocardiocyte apoptosis, gap junction pathophysiology, supraventricular/ventricular arrhythmias, and sudden cardiac death42. The gene discussed is DSC3; the disease is cardiac arrhythmia.