In contrast, in a patient with a TiME-II tumor (MPM.004; HLA-A*26:01, HLA-DRB1*08:01, and HLA-DRB1*13:01), the NF2E166V neoantigens (QVELLPKRVINLY and RGFLAQVELLPKRVI) with high predicted affinity to HLA-A and HLA-DRB1, respectively, were demonstrated at low abundance, along with low expression of its corresponding HLA proteins (Figure 3D). Here, HLA-DRB1 is linked to neoplasm.