TiME-I tumors also contained a greater frequency of HLA-DR+ cancer cells, which positively correlate with response to checkpoint blockade in melanoma patients (20) and which we have found to demonstrate increased expression of cytokines (IL-10, IL-6, and TNF-α) and phosphorylated transcription factors (HIF-1A, cPARP, and STAT3) in MPM (Supplemental Figure 5). This evidence concerns the gene HIF1A and melanoma.